Article
A DOB allele encoding an amino acid substitution (Phe62Ser) resulting in a Dombrock null phenotype.
Transfusion - 1 Aug 2007
Westhoff Connie, Vege Sunitha, Yazdanbakhsh Karina, Wylie Dwane, Razib Mohammad, Hue-Roye Kim, Halverson Gregory, Read Sandy, Whiteoak Elizabeth, Nickle Pam, Maurer Joan, Kavitsky Donna, Nance Sandra, Reid Marion E
Abstract excerpt
BACKGROUND: The gene polymorphisms responsible for the antigens Doa, Dob, Hy, and Joa in the Dombrock (Do) blood group system have been identified. Four different mutations have been reported to cause the Dombrock null [Gy(a-)] phenotype. These include splice mutations, an eight-nucleotide deletion, and insertion of a stop codon. Here a Dombrock null caused by a single-amino-acid substitution in the full-length...
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