Article
Molecular basis of the Dombrock null phenotype.
Transfusion - 1 Nov 2001
Rios M, Hue-Roye K, Storry J R, Lee T, Miller J L, Reid M E
Abstract excerpt
BACKGROUND: The Dombrock blood group system consists of two antithetical antigens, Do(a) and Do(b), and three high-incidence antigens, Gregory (Gy(a)), Holley (Hy), and Joseph (Jo(a)). The null phenotype of the Dombrock blood group system (Do(null)) was identified when it was found that Gy(a-) RBCs also lack Do(a), Do(b), Hy, and Jo(a). STUDY DESIGN AND METHODS: DNA from three Gy(a-) persons was analyzed. PCR...
Topics
- Amino Acid Sequence
- Base Sequence
- Blood Group Antigens
- DNA
- DNA, Complementary
- DNA, Recombinant
- Exons
- Frameshift Mutation
- Genome
- Humans
- Isoantigens
- Molecular Sequence Data
- Phenotype