Article
Hemochromatosis-associated gene mutations in patients with myelodysplastic syndromes with refractory anemia with ringed sideroblasts.
American journal of hematology - 1 Dec 2007
Nearman Zachary P, Szpurka Hadrian, Serio Bianca, Warshawksy Ilka, Theil Karl, Lichtin Alan, Sekeres Mikkael A, Maciejewski Jaroslaw P
Abstract excerpt
We observed increased ferritin levels in newly diagnosed MDS-RARS patients without transfusional iron-overload. Hence, we hypothesized RARS patients may harbor hemochromatosis-related mutations, which could contribute to the pathophysiology of this myelodysplastic syndromes (MDS) subset. We studied a cohort of 140 MDS patients: 42 with RARS, 10 with increased ringed sideroblasts, and 96 with other forms of MDS...
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