Article
JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis.
Haematologica - 1 Jan 2008
Schmitt-Graeff Annette H, Teo Soon-Siong, Olschewski Manfred, Schaub Franz, Haxelmans Sabine, Kirn Andreas, Reinecke Petra, Germing Ulrich, Skoda Radek C
Abstract excerpt
BACKGROUND: Refractory anemia with ringed sideroblasts and marked thrombocytosis (RARS-T) was recently shown to be a JAK2-V617F mutation-related disorder. To determine the frequency and the prognostic significance of this mutation, we retrospectively evaluated 23 patients with platelet counts more than 600 x 10(9)/L, 15% ringed sideroblasts or more, and at least erythroid marrow dysplasia. DESIGN AND METHODS: An...
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