Article
Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease.
Human genetics - 1 Nov 2007
Chen Zhiyong, Takahashi Megumi, Naruse Taeko, Nakajima Toshiaki, Chen Yi-Wen, Inoue Yoshinori, Ishikawa Isao, Iwai Takehisa, Kimura Akinori
Abstract excerpt
Buerger disease (BD) is an occulusive vascular disease of unknown etiology. Although cigarette smoking is a well-known risk factor of BD, genetic factors may also play a role in the etiology. Because chronic bacterial infection such as oral periodontitis is suggested to be involved in the pathogenesis of BD, gene polymorphisms involved in the infectious immunity might be associated with BD as the genetic...
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