Article
A single nucleotide polymorphism in the 3'-untranslated region of MyD88 gene is associated with Buerger disease but not with Takayasu arteritis in Japanese.
Journal of human genetics - 1 Jul 2011
Chen Zhiyong, Nakajima Toshiaki, Inoue Yoshinori, Kudo Toshifumi, Jibiki Masatoshi, Iwai Takehisa, Kimura Akinori
Abstract excerpt
Buerger disease (BD) and Takayasu arteritis (TA) are rare vascular disorders. Although their etiology and pathogenesis have not been elucidated, several studies have suggested the involvement of innate immunity. Myeloid differentiation primary-response protein 88 (MyD88) is a key signaling adaptor for all Toll-like receptors, which have a central role in innate immunity. In the present study, we evaluated the...
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