Article
Clinical application of human β-defensin and CD14 gene polymorphism in evaluating the status of chronic inflammation.
Journal of translational medicine - 19 Sept 2012
Loo Wings T Y, Bai Lan-jun, Fan Chang-bin, Yue Yuan, Dou Yi-ding, Wang Min, Liang Hao, Cheung Mary N B, Chow Louis W C, Li Jin-le, Tian Ye, Qing Liu
Abstract excerpt
BACKGROUND: Periodontitis is a common disease that affects the periodontal tissue supporting the teeth. This disease is attributed to multiple risk factors, including diabetes, cigarette smoking, alcohol, pathogenic microorganisms, genetics and others. Human beta-defensin-1 (hBD-1) is a cationic antimicrobial peptide with cysteine-rich ß-sheets and broad-spectrum antimicrobial activity. CD14 is a protein involved...
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