Article
Cytotoxic T lymphocyte antigen 4 gene polymorphism associated with ST-segment elevation acute myocardial infarction.
Circulation journal : official journal of the Japanese Circulation Society - 1 Aug 2007
Yip Hon-Kan, Wang Pei-wen, Chang Li-Teh, Youssef Ali A, Sheu Jiunn-Jye, Lee Fan-Yen, Wu Chiung-Jen
Abstract excerpt
BACKGROUND: Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a particularly important molecule in down-regulating T-cell expansion and cytokine production. The purpose of the present study was to determine the frequency distribution of an A/G single nucleotide polymorphism at position 49 in exon 1 of the CTLA-4 gene, which may be a functional related-genetic risk marker for the development of ST-segment elevation...
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