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Article

Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels.

Circulation journal : official journal of the Japanese Circulation Society - 1 Jun 2007

Shimizu Masakatsu, Kanazawa Kenji, Hirata Ken-ichi, Ishida Tatsuro, Hiraoka Eiji, Matsuda Yasuaki, Iwai Chikao, Miyamoto Yoshitomo, Hashimoto Masayoshi, Kajiya Teishi, Akita Hozuka, Yokoyama Mitsuhiro

Abstract excerpt

BACKGROUND: Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment. The local expression of EL could influence atherogenesis directly, in addition to its systemic role in HDL metabolism. The EL gene has a common 584C/T polymorphism, but it is unclear whether this polymorphism is associated with HDL-C levels or acute myocardial...

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PMID: 17526978
DOI: 10.1253/circj.71.842

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