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Article

Huh-7: a human "hemochromatotic" cell line.

Hepatology (Baltimore, Md.) - 1 Feb 2010

Vecchi Chiara, Montosi Giuliana, Pietrangelo Antonello

Abstract excerpt

UNLABELLED: Hereditary hemochromatosis (HC) is commonly associated with homozygosity for the cysteine-to-tyrosine substitution at position 282 (C282Y) of the HFE protein. This mutation prevents HFE from binding beta(2)-microglobulin (beta(2)M) and reaching the cell surface. We have discovered that a widely used hepatoma cell line, Huh-7, carries a HFE mutation similar to that associated with human HC. By HFE gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20017200
DOI: 10.1002/hep.23410

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Huh-7: a human "hemochromatotic" cell line.PMID 20017200Read ↗

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The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand bindingSemantic proximity Read ↗

Differential HFE allele expression in hemochromatosis heterozygotes.Semantic proximity Read ↗

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The hereditary hemochromatosis protein HFE and its chaperone beta2-microglobulin localise predominantly to the endosomal-recycling compartment.Semantic proximity Read ↗

Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells.Semantic proximity Read ↗

The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin.Semantic proximity Read ↗

Over-expression of wild-type and mutant HFE in a human melanocytic cell line reveals an intracellular bridge between MHC class I pathway and transferrin iron uptake.Semantic proximity Read ↗

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.Semantic proximity Read ↗

[From gene to disease; HFE-mutations in primary haemochromatosis].Semantic proximity Read ↗

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosisSemantic proximity Read ↗

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