Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients.

doi:10.1182/blood-2013-12-546283

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Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients.

Blood - 26 Jun 2014

Tassara Michela, Döhner Konstanze, Brossart Peter, Held Gerhard, Götze Katharina, Horst Heinz-A, Ringhoffer Mark, Köhne Claus-Henning, Kremers Stephan, Raghavachar Aruna, Wulf Gerald, Kirchen Heinz, Nachbaur David, Derigs Hans Günter, Wattad Mohammed, Koller Elisabeth, Brugger Wolfram, Matzdorff Axel, Greil Richard, Heil Gerhard, Paschka Peter, Gaidzik Verena I, Göttlicher Martin, Döhner Hartmut, Schlenk Richard F

Abstract excerpt

The outcome of patients with acute myeloid leukemia who are older than 60 years has remained poor because of unfavorable disease characteristics and patient-related factors. The randomized German-Austrian AML Study Group 06-04 protocol was designed on the basis of in vitro synergistic effects of valproic acid (VPA) and all-trans retinoic acid with chemotherapy. Between 2004 and 2006, 186 patients were randomly...

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PMID: 24797300
DOI: 10.1182/blood-2013-12-546283

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NPM1

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