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Article

Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes.

Journal of gastroenterology and hepatology - 1 Sept 2007

Schumacher Guido, Hoffmann Janine, Cramer Thorsten, Spinelli Antonino, Jacob Dietmar, Bahra Marcus, Pratschke Johann, Pfitzmann Robert, Schmidt Sven, Lage Hermann

Abstract excerpt

BACKGROUND AND AIM: Chemoresistance often leads to loss of the last treatment option for cancer. 2-Methoxyestradiol (2-ME2) has been shown to inhibit tumor growth. The aim was to examine the efficacy of 2-ME2 on multidrug-resistant human cells from pancreatic and gastric cancer. METHODS: We investigated the impact of 2-ME2 on multidrug-resistant cells derived from human pancreatic and gastric cancer cells that...

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Identifiers

PMID: 17645459
DOI: 10.1111/j.1440-1746.2007.05033.x

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