Article
Genetic association studies of neurotensin gene and restless legs syndrome in French Canadians.
Sleep medicine - 1 Mar 2008
Xiong Lan, Levchenko Anastasia, Montplaisir Jacques, Rivière Jean-Baptiste, Thibodeau Pascale, St-Onge Judith, Gaspar Claudia, Desautels Alex, Lespérance Paul, Chouinard Sylvain, Turecki Gustavo, Rouleau Guy A
Abstract excerpt
BACKGROUND AND PURPOSE: The neurotensin gene (NTS), a known dopamine modulator, is located within the candidate region for the first genetic locus of restless legs syndrome (RLS1) on chromosome 12q. Though no causative mutation was found in selected patients in a previous mutation analysis, the involvement of NTS in RLS cannot be completely excluded as a potential positional and functional candidate gene. The...
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