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Article

Cadmium activation of wild-type and constitutively active estrogen receptor alpha.

Frontiers in endocrinology - 1 Jan 2024

Psaltis John B, Wang Qiaochu, Yan Gai, Gahtani Reem, Huang Nanxi, Haddad Bassem R, Martin Mary Beth

Abstract excerpt

The estrogen receptor alpha (ERα) plays a central role in the etiology, progression, and treatment of breast cancers. Constitutively activating somatic mutations Y537S and D538G, in the ligand binding domain (LBD) of ESR1, are associated with acquired resistance to endocrine therapies. We have previously shown that the metalloestrogen calcium activates ERα through an interaction with the LBD of the receptor. This...

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Identifiers

PMID: 39184142
DOI: 10.3389/fendo.2024.1380047
PMCID: PMC11341946

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