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Article

Activation of estrogen receptor-alpha by the heavy metal cadmium.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2000

Stoica A, Katzenellenbogen B S, Martin M B

Abstract excerpt

Previous studies from this laboratory have shown that the heavy metal cadmium (Cd) mimics the effects of estradiol in estrogen-responsive breast cancer cell lines. To understand the mechanism by which cadmium activates estrogen receptor-alpha (ER-alpha), the ability of cadmium to bind to and activate wild-type and various mutants of ER-alpha was examined. When tested in transient cotransfection assays in COS-1...

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Identifiers

PMID: 10770491
DOI: 10.1210/mend.14.4.0441

Genes

GAL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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