Article
Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer.
Endocrine-related cancer - 1 Jun 2007
Vaclavicek Annika, Bermejo Justo Lorenzo, Schmutzler Rita K, Sutter Christian, Wappenschmidt Barbara, Meindl Alfons, Kiechle Marion, Arnold Norbert, Weber Bernhard H F, Niederacher Dieter, Burwinkel Barbara, Bartram Claus R, Hemminki Kari, Försti Asta
Abstract excerpt
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway mediates the signals of a wide range of cytokines, growth factors and hormones. Thus, aberrant activation of the JAK/STAT pathway may predispose to malignancy due to deregulation of proliferation, differentiation or apoptosis. In this study, we investigated whether genetic variation in the JAK2 gene and the STAT gene region...
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