Article
Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer.
Endocrine-related cancer - 1 Jun 2007
Vaclavicek Annika, Bermejo Justo Lorenzo, Schmutzler Rita K, Sutter Christian, Wappenschmidt Barbara, Meindl Alfons, Kiechle Marion, Arnold Norbert, Weber Bernhard H F, Niederacher Dieter, Burwinkel Barbara, Bartram Claus R, Hemminki Kari, Försti Asta
Abstract excerpt
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway mediates the signals of a wide range of cytokines, growth factors and hormones. Thus, aberrant activation of the JAK/STAT pathway may predispose to malignancy due to deregulation of proliferation, differentiati...
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