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Article

Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.

Oncogene - 10 Jan 2008

Takeyama K, Monti S, Manis J P, Dal Cin P, Getz G, Beroukhim R, Dutt S, Aster J C, Alt F W, Golub T R, Shipp M A

Abstract excerpt

p53-Binding protein 1 (53BP1) encodes a critical checkpoint protein that localizes to sites of DNA double-strand breaks (DSBs) and participates in DSB repair. Mice that are 53bp1 deficient or hemizygous have an increased incidence of lymphoid malignancies. However, 53BP1 abnormalities in primary human tumors have not been described. By combining high-density single nucleotide polymorphism (HD SNP) array data and...

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Share to Chromosome Aberrations
Share to Chromosomes, Human, Pair 15

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

Share to Intracellular Signaling Peptides and Proteins

Share to Lymphoma, Large B-Cell, Diffuse

Share to Oligonucleotide Array Sequence Analysis

Share to Tumor Suppressor p53-Binding Protein 1

Source

Identifiers

PMID: 17637749
DOI: 10.1038/sj.onc.1210650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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