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Article

The effect of epigenetic silencing and TP53 mutation on the expression of DLL4 in human cancer stem disorder.

Oncotarget - 27 Sept 2016

Yao Zhixing, Sherif Zaki A

Abstract excerpt

The Li-Fraumeni Syndrome (LFS), a genetically rare heterogeneous cancer syndrome, is characterized primarily by a germline p53 (TP53) gene mutation. We recently discovered a balanced reciprocal chromosomal translocation t(11;15)(q23;q15) in the non-cancerous skin fibroblasts of a bilateral breast cancer patient in LFS family. This prompted us to investigate the breakpoint region of the translocation, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

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Source

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Identifiers

PMID: 27542210
DOI: 10.18632/oncotarget.11316
PMCID: PMC5325341

Genes

DLL4
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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