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Female Reproductive Traits and Late-Life Hormone-Sensitive Cancer Risk: A Mendelian Randomization Study.

Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2026

Li Zijun, Peng Qinghui, Lin Yidie, Li Zengjun, Li Xuechao, Zhao Jian, Zhu Cairong

Abstract excerpt

Ovarian reserve is a crucial component of female reproductive traits. However, the possible causal effects between ovarian reserve and hormone-sensitive cancers remain incompletely understood. In this study, two-sample Mendelian randomization (MR) analyses were performed to assess potential causal effects of reproductive traits on hormone-sensitive cancers. In addition, multivariable MR was applied to determine...

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PMID: 41560424
DOI: 10.1158/1940-6207.CAPR-25-0176

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AMH

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