Article
AMH and AMHR2 genetic variants in Chinese women with primary ovarian insufficiency and normal age at natural menopause.
Reproductive biomedicine online - 1 Sept 2014
Qin Chunrong, Yuan Zhen, Yao Jilong, Zhu Wenjie, Wu Weiqing, Xie Jiansheng
Abstract excerpt
The aim of this study was to investigate the role of the anti-Müllerian hormone (AMH) signalling pathway in the pathophysiology of idiopathic primary ovarian insufficiency (POI) and age at natural menopause (ANM) using a genetic approach. DNA sequencing was used to detect the genotype distribution and allele frequency of the genes AMH and AMH receptor II (AMHR2) in 120 cases of idiopathic POI and 120 normal-ANM...
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