Article
UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation.
The FEBS journal - 1 Aug 2007
McGilvray Roger, Walker Mark, Bartholomew Chris
Abstract excerpt
The EVI1 transcriptional repressor is critical to the normal development of a variety of tissues and participates in the progression of acute myeloid leukaemias. The repressor domain (Rp) was used to screen an adult human kidney yeast two-hybrid library and a novel binding partner designated ubiquitously expressed transcript (UXT) was isolated. Enforced expression of UXT in Evi1-expressing Rat1 fibroblasts...
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