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Article

Essential role of stromally induced hedgehog signaling in B-cell malignancies.

Nature medicine - 1 Aug 2007

Dierks Christine, Grbic Jovana, Zirlik Katja, Beigi Ronak, Englund Nathan P, Guo Gui-Rong, Veelken Hendrik, Engelhardt Monika, Mertelsmann Roland, Kelleher Joseph F, Schultz Peter, Warmuth Markus

Abstract excerpt

Interaction of cancer cells with their microenvironment generated by stromal cells is essential for tumor cell survival and influences the localization of tumor growth. Here we demonstrate that hedgehog ligands secreted by bone-marrow, nodal and splenic stromal cells function as survival factors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17632527
DOI: 10.1038/nm1614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17632527-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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