Article
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007
Peacock Craig D, Wang Qiuju, Gesell Gregory S, Corcoran-Schwartz Ian M, Jones Evan, Kim Jynho, Devereux Wendy L, Rhodes Jonathan T, Huff Carol A, Beachy Philip A, Watkins D Neil, Matsui William
Abstract excerpt
The cancer stem cell hypothesis suggests that malignant growth depends on a subset of tumor cells with stem cell-like properties of self-renewal. Because hedgehog (Hh) signaling regulates progenitor cell fate in normal development and homeostasis, aberrant pathway activation might be involved in the maintenance of such a population in cancer. Indeed, mutational activation of the Hh pathway is associated with...
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