Article
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
The Journal of biological chemistry - 21 Sept 2007
Hong Bum Soo, Senisterra Guillermo, Rabeh Wael M, Vedadi Masoud, Leonardi Roberta, Zhang Yong-Mei, Rock Charles O, Jackowski Suzanne, Park Hee-Won
Abstract excerpt
Pantothenate kinase (PanK) catalyzes the first step in CoA biosynthesis and there are three human genes that express four isoforms with highly conserved catalytic core domains. Here we report the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA, a feedback inhibitor. Each monomer adopts a fold of the actin kinase superfamily and the inhibitor-bound structures...
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