Article
Lack of association between gene sequence variations of platelet membrane receptors and aspirin responsiveness detected by the PFA-100 system in patients with coronary artery disease.
Platelets - 1 Dec 2006
Bernardo Esther, Angiolillo Dominick J, Ramírez Celia, Cavallari Ugo, Trabetti Elisabetta, Sabaté Manel, Hernández Rosana, Moreno Raul, Escaned Javier, Alfonso Fernando, Bañuelos Camino, Costa Marco A, Bass Theodore A, Pignatti Pier Franco, Macaya Carlos, Fernandez-Ortiz Antonio
Abstract excerpt
Platelet membrane receptors play a pivotal role in thrombus formation. Expression of platelet membrane receptors are under genetic control and gene sequence variations of receptors pivotal to thrombotic formation have been hypothesized to contribute to different degrees of individual response to aspirin. The aim of the present study was to investigate the impact of functional genetic polymorphisms of platelet...
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