Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease-relevant insults.

doi:10.1016/s0196-9781(03)00106-2

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Article

Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease-relevant insults.

Peptides - 1 Apr 2003

Yamagishi Yohichi, Hashimoto Yuichi, Niikura Takako, Nishimoto Ikuo

Abstract excerpt

Humanin (HN) is a secretory peptide that inhibits neurotoxicity by various Alzheimer's disease-relevant insults. We have so far identified that the substitution of Leu9 for Arg nullifies the extracellular secretion of HN. Here we comprehensively investigate the amino acid requirement of HN essential for its secretion and for its neuroprotective function. Intracellulary expressed HN-EGFP (EGFP N-terminally fused...

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PMID: 12860203
DOI: 10.1016/s0196-9781(03)00106-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.