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Article

Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jul 2007

Skelly Christopher L, Chandiwal Amito, Vosicky James E, Weichselbaum Ralph R, Roizman Bernard

Abstract excerpt

Injury caused by distention of the arterial wall by balloon angioplasty can result in apoptosis and vascular smooth muscle cell proliferation. Here, we report that a brief exposure of the arterial lumen to a genetically engineered, attenuated herpes simplex virus 1 blocks activation of caspase 3-...

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Identifiers

PMID: 17626787
DOI: 10.1073/pnas.0705429104
PMCID: PMC1941493

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17626787-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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