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Article

Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence.

Journal of virology - 1 May 2009

Kelley-Clarke Brenna, De Leon-Vazquez Erika, Slain Katherine, Barbera Andrew J, Kaye Kenneth M

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) LANA is an 1,162-amino-acid protein that tethers terminal repeat (TR) DNA to mitotic chromosomes to mediate episome persistence in dividing cells. C-terminal LANA self-associates to bind TR DNA. LANA contains independent N- and C-terminal chromosome binding regions. N-terminal LANA binds histones H2A/H2B to attach to chromosomes, and this binding is essential for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Herpesvirus 8, Human

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Source

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Identifiers

PMID: 19225000
DOI: 10.1128/JVI.02395-08
PMCID: PMC2668501

Genes

BAX
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence.PMID 19225000Read ↗

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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Mediates Episome Persistence through <i>cis</i> -Acting Terminal Repeat (TR) Sequence and Specifically Binds TR DNASemantic proximity Read ↗

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The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Supports Latent DNA Replication in Dividing CellsSemantic proximity Read ↗

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