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Article

Species variation in pulmonary endothelial aminopeptidase P activity.

The Journal of pharmacology and experimental therapeutics - 1 Dec 1991

Chen X, Orfanos S E, Ryan J W, Chung A Y, Hess D C, Catravas J D

Abstract excerpt

Pulmonary endothelial aminopeptidase P (AmP) may be an important contributor to the inactivation of circulating bradykinin in certain species. To examine this possibility, we measured AMP activity in vivo and in vitro using Arg-Pro-Pro-[3H]benzylamide (3H-APPB) as substrate under conditions of first order enzyme kinetics. Utilizing multiple indicator dilution techniques, metabolism of 3H-APPB to Arg and...

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PMID: 1762077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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