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Article

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

7 Jul 2020

Abstract excerpt

Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we present a novel molecular mechanism for COVID-19 that provides therapeutic intervention points that can be addressed with existing FDA-approved pharmaceuticals. The entry point for the virus is ACE2, which is a component of the counteracting hypotensive axis of RAS. Bradykinin is a potent part of the vasopressor system that...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
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PMID: 32633718
DOI: 10.7554/elife.59177

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