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Article

Towards an understanding of the functional significance of N-terminal domain divergence in human AMP deaminase isoforms.

Pharmacology & therapeutics - 1 Jan 2000

Sabina R L, Mahnke-Zizelman D K

Abstract excerpt

Human AMP deaminase (AMPD; EC 3.5.4.6) isoforms are encoded by a multigene family and have conserved C-terminal domains that contain catalytic residues and an ATP-binding site. N-terminal domains diverge dramatically, yet are conserved when compared across mammalian species. Cross-species conservation of entire gene-specific polypeptides (e.g., rat versus human AMPD1) suggests that divergent N-terminal domains...

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Source

Identifiers

PMID: 11008004
DOI: 10.1016/s0163-7258(00)00040-1

Genes

AMPD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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