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Article

Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion.

Molecular cancer therapeutics - 1 Jul 2007

Tsao Anne S, He Dandan, Saigal Babita, Liu Suyu, Lee J Jack, Bakkannagari Srinivasa, Ordonez Nelson G, Hong Waun Ki, Wistuba Ignacio, Johnson Faye M

Abstract excerpt

Malignant pleural mesothelioma (MPM) is a deadly disease with few systemic treatment options. One potential therapeutic target, the non-receptor tyrosine kinase c-Src, causes changes in proliferation, motility, invasion, survival, and angiogenesis in cancer cells and may be a valid therapeutic target in MPM. To test this hypothesis, we determined the effects of c-Src inhibition in MPM cell lines and examined...

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Identifiers

PMID: 17620427
DOI: 10.1158/1535-7163.MCT-07-0052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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