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Article

p107 Is a Crucial Regulator for Determining the Adipocyte Lineage Fate Choices of Stem Cells

21 Jan 2014

Abstract excerpt

Thermogenic (beige and brown) adipocytes protect animals against obesity and metabolic disease. However, little is known about the mechanisms that commit stem cells toward different adipocyte lineages. We show here that p107 is a master regulator of adipocyte lineage fates, its suppression required for commitment of stem cells to the brown-type fate. p107 is strictly expressed in the stem cell compartment of...

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PMID: 24449206
DOI: 10.1002/stem.1637

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