Article
Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.
The Journal of nutritional biochemistry - 1 Apr 2008
Guri Amir J, Hontecillas Raquel, Ferrer Gerardo, Casagran Oriol, Wankhade Umesh, Noble Alexis M, Eizirik Decio L, Ortis Fernanda, Cnop Miriam, Liu Dongmin, Si Hongwei, Bassaganya-Riera Josep
Abstract excerpt
Abscisic acid (ABA) is a natural phytohormone and peroxisome proliferator-activated receptor gamma (PPARgamma) agonist that significantly improves insulin sensitivity in db/db mice. Although it has become clear that obesity is associated with macrophage infiltration into white adipose tissue (WAT...
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