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Article

Differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein.

Matrix biology : journal of the International Society for Matrix Biology - 1 Sept 2007

Cheng Christina, Conte Evan, Pleshko-Camacho Nancy, Hidaka Chisa

Abstract excerpt

Despite the knowledge that superficial zone chondrocytes (SZC, located within 100 mum of the articular surface) and deep zone chondrocytes (DZC, located near the calcified zone) have distinct phenotypes, previous studies on bone morphogenetic proteins (BMPs) have not differentiated its effects on SZC versus DZC. Using a pellet culture model we have compared phenotype, morphology and matrix accumulation in SZC and...

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Source

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Identifiers

PMID: 17618099
DOI: 10.1016/j.matbio.2007.05.006
PMCID: PMC2080576

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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