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Dedifferentiation and Redifferentiation of Articular Chondrocytes from Surface and Middle Zones: Changes in MicroRNAs-221/-222, -140, and -143/145 Expression

29 Nov 2012

Abstract excerpt

Articular cartilage contains three functional zones (superficial, middle, and deep) characterized by distinct structure, composition, and biomechanical properties. One of the unsolved major challenges in cartilage tissue engineering is to produce tissue that mimics the zonal organization of the native articular cartilage. An increasing number of studies aim to design zonal organization into tissue-engineered...

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PMID: 23190381
DOI: 10.1089/ten.tea.2012.0055

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