Article
IgE-Fc epsilonRI-mast cell axis in the allergic cycle.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Aug 1998
Pawankar R, Ra C
Abstract excerpt
The IgE and allergen dependent activation of mast cells via the high affinity IgE receptor (Fc epsilonRI) resulting in the release of inflammatory mediators is critical to the pathogenesis of atopic diseases like bronchial asthma and allergic rhinitis. However, mast cells are also involved in certain IgE-independent biological responses, and recent studies have highlighted the role of mast cells in host defense....
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