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Article

Global DNA methylation measured by liquid chromatography-tandem mass spectrometry: analytical technique, reference values and determinants in healthy subjects.

Clinical chemistry and laboratory medicine - 1 Jan 2007

Kok Robert M, Smith Desirée E C, Barto Rob, Spijkerman Annemieke M W, Teerlink Tom, Gellekink Henk J, Jakobs Cornelis, Smulders Yvo M

Abstract excerpt

BACKGROUND: Alterations in global DNA methylation are implicated in various pathobiological processes. We describe a liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method for determination of cytosine and 5-methylcytosine in DNA. METHODS: DNA was hydrolyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17617036
DOI: 10.1515/CCLM.2007.137

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MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17617036-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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