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Article

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic β-cells

5 Jul 2007

Abstract excerpt

CHOP-10 (GADD153/DDIT-3) is a bZIP protein involved in differentiation and apoptosis. Its expression is induced in response to stresses such as nutrient deprivation, perturbation of the endoplasmic reticulum, redox imbalance, and UV exposure. Here we show that CHOP expression is induced in cultured pancreatic beta-cells maintained in a basal glucose concentration of 5.5 mM and repressed by stimulatory glucose...

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Share to Endoplasmic Reticulum Stress and Disease
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PMID: 17615236
DOI: 10.1073/pnas.0704618104

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