Article
Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus.
The Biochemical journal - 1 Oct 2007
Ohradanova Anna, Vullo Daniela, Kopacek Juraj, Temperini Claudia, Betakova Tatiana, Pastorekova Silvia, Pastorek Jaromir, Supuran Claudiu T
Abstract excerpt
The N-terminal region of a 32 kDa cell-surface-binding protein, encoded by the D8L gene of vaccinia virus, shows sequence homology to CAs (carbonic anhydrases; EC 4.2.1.1). The active CAs catalyse the reversible hydration of CO2 to bicarbonate participating in many physiological processes. The CA-like domain of vaccinia protein [vaccCA (vaccinia virus CA-like protein)] contains one of the three conserved...
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