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Article

Analysis of polymorphisms in the colchicine binding site of tubulin in colchicine-resistant familial Mediterranean fever patients.

Molecular biology reports - 1 Nov 2020

Akbaba Tayfun Hilmi, Ustabas Gizem, Kasap-Cuceloglu Muserref, Ozen Seza, Balci-Peynircioglu Banu

Abstract excerpt

Familial Mediterranean fever is a hereditary autoinflammatory syndrome. The typical treatment for the disease is colchicine. However, a subset of patients are not responsive to colchicine. In this study, polymorphisms in the colchicine-binding site of the TUBB1 gene, which encodes a tubulin isoform specific to leukocytes, were investigated in patients with colchicine-resistant disease. FMF patients who were...

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PMID: 33161498
DOI: 10.1007/s11033-020-05957-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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