Article
A survey of resistance to colchicine treatment for French patients with familial Mediterranean fever.
Orphanet journal of rare diseases - 16 Mar 2017
Corsia Alice, Georgin-Lavialle Sophie, Hentgen Véronique, Hachulla Eric, Grateau Gilles, Faye Albert, Quartier Pierre, Rossi-Semerano Linda, Koné-Paut Isabelle
Abstract excerpt
BACKGROUND: Colchicine is the standard treatment for familial Mediterranean fever (FMF), preventing attacks and inflammatory complications. True resistance is rare and yet not clearly defined. We evaluated physicians' definition of colchicine resistance and report how they manage it. PATIENTS AND METHODS: We recruited patients with a clinical diagnosis of FMF, one exon-10 Mediterranean fever (MEFV) gene mutation...
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