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Article

Combined targeting of MEK/MAPK and PI3K/Akt signalling in multiple myeloma.

British journal of haematology - 1 Nov 2012

Steinbrunn Torsten, Stühmer Thorsten, Sayehli Cyrus, Chatterjee Manik, Einsele Hermann, Bargou Ralf C

Abstract excerpt

So-called RAS-dependent pathways, such as those signalling via mitogen-activated protein kinase kinase (MEK)/mitogen-activated protein kinase (MAPK) and phosphoinositide-3 kinase (PI3K)/Akt, are implicated in proliferation and survival of multiple myeloma (MM) cells. However, the effects of their combined blockade and its potential therapeutic utility for the treatment of RAS-mutated MM have not systematically...

Topics

Apoptosis
Cell Line, Tumor
Enzyme Inhibitors
Genes, ras
Humans
MAP Kinase Signaling System
Mitogen-Activated Protein Kinases
Multiple Myeloma
Mutation
Phosphatidylinositol 3-Kinases
Phosphoinositide-3 Kinase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-akt

ras Proteins

Source

Identifiers

PMID: 22985491
DOI: 10.1111/bjh.12039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22985491-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Combined targeting of MEK/MAPK and PI3K/Akt signalling in multiple myeloma.PMID 22985491Read ↗

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