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Article

Regulation of the α-Crystallin Geneacr2by the MprAB Two-Component System ofMycobacterium tuberculosis

30 Jun 2007

Abstract excerpt

Coordinated regulation of molecular chaperones is an important feature of the bacterial stress response. The small molecular chaperone gene acr2 of Mycobacterium tuberculosis is activated by exposure to several stresses, including heat and the detergent sodium dodecyl sulfate (SDS). In this study, we show that acr2 is directly regulated by the MprAB two-component system, and that MprAB has both positive and...

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PMID: 17601788
DOI: 10.1128/jb.00492-07

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