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Article

Mapping rheumatoid factor binding sites using genetically engineered, chimeric IgG antibodies.

DNA and cell biology - 1 Apr 1992

Bonagura V R, Artandi S E, Agostino N, Tao M H, Morrison S L

Abstract excerpt

We are using chimeric IgG antibodies consisting of murine variable regions joined to human constant regions as rheumatoid factor (RF) binding substrates to localize and map IgM RF binding sites on IgG. Using chimeric antibodies in a modified RF ELISA, we showed that RFs from rheumatoid arthritis...

Topics

Animals
Antibodies, Monoclonal
Binding Sites, Antibody
Carbohydrate Metabolism
Chimera
Genetic Engineering
Humans
Immunoglobulin G
Immunoglobulin M
Mice
Mutation
Rheumatoid Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1567557
DOI: 10.1089/dna.1992.11.245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1567557-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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