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Article

PTCH mutations are not mainly involved in the pathogenesis of sporadic trichoblastomas.

Human pathology - 1 Oct 2007

Hafner Christian, Schmiemann Viola, Ruetten Arno, Coras Brigitte, Landthaler Michael, Reifenberger Julia, Vogt Thomas

Abstract excerpt

Trichoblastomas are rare, benign tumors of the appendix in human skin. The histopathology comprises elements of basal cell carcinoma and trichoepithelioma with a variable degree of follicular differentiation. Both basal cell carcinoma and trichoepithelioma reveal alterations of PTCH, the human homolog of the Drosophila segment polarity patched gene. Furthermore, heterozygous PTCH knockout mice develop...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17597182
DOI: 10.1016/j.humpath.2007.02.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PTCH mutations are not mainly involved in the pathogenesis of sporadic trichoblastomas.PMID 17597182Read ↗

Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: support for a gatekeeper mechanism in skin tumorigenesis.Semantic proximity Read ↗

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.Semantic proximity Read ↗

PTCH mutations: distribution and analyses.Semantic proximity Read ↗

PTCH mutations and deletions in patients with typical nevoid basal cell carcinoma syndrome and in patients with a suspected genetic predisposition to basal cell carcinoma: a French study.Semantic proximity Read ↗

PTEN Hamartoma Tumor Syndrome: Skin Manifestations and Insights Into Their Molecular PathogenesisSemantic proximity Read ↗

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.Semantic proximity Read ↗

Clinicopathologic and molecular characterization of a series of sporadic trichoblastic neoplasms.Semantic proximity Read ↗

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1Semantic proximity Read ↗

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1Semantic proximity Read ↗

No evidence for mutations in exons 1, 8 and 18 of the patched gene in sporadic skin lesions of Brazilian patients.Semantic proximity Read ↗

Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident.Semantic proximity Read ↗

Phenotype variability in tumor disorders of the skin appendages associated with mutations in the CYLD gene.Semantic proximity Read ↗

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