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Article

Clinicopathologic and molecular characterization of a series of sporadic trichoblastic neoplasms.

Virchows Archiv : an international journal of pathology - 1 Mar 2026

Dehner Carina A, Honaker Eric C, Abu-Salah Asma K, Umphress Brandon A, Mopuri Rohini, Fadra Numrah, Piatkowski Bryan, Kowal Rachel, Warren Simon J, Al-Omari Ahmed, Guo Ruifeng

Abstract excerpt

Trichoblastoma (TB) is a benign primitive follicular neoplasm that can occur in the setting of Brooke-Spiegler syndrome (CYLD mutations), in association with nevus sebaceous (mosaic HRAS mutations), or sporadically. We studied the histopathologic and molecular features of 16 sporadic trichoblastic neoplasms, including a case of trichogerminoma and a case of trichoblastic carcinoma arising within a TB. Sixteen...

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Source

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Identifiers

PMID: 41203975
DOI: 10.1007/s00428-025-04335-8
PMCID: PMC12963137

Genes

CYLD
FOXK1
GRHL1
HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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