Article
No evidence for mutations in exons 1, 8 and 18 of the patched gene in sporadic skin lesions of Brazilian patients.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Apr 2003
Granja F, Santarosa P L, Leite J L A A P, Ward L S
Abstract excerpt
There is strong evidence that the patched (PTCH) gene is a gene for susceptibility to the nevoid basal cell carcinoma syndrome. PTCH has also been shown to mutate in both familial and sporadic basal cell carcinomas. However, mutations of the gene seem to be rare in squamous cell carcinomas. In order to characterize the role of the gene in the broader spectrum of sporadic skin malignant and pre-malignant lesions,...
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