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Article

Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone.

The Journal of biological chemistry - 31 Aug 2007

Askew Emily B, Gampe Robert T, Stanley Thomas B, Faggart Jonathan L, Wilson Elizabeth M

Abstract excerpt

The androgen receptor (AR) is transcriptionally activated by high affinity binding of testosterone (T) or its 5alpha-reduced metabolite, dihydrotestosterone (DHT), a more potent androgen required for male reproductive tract development. The molecular basis for the weaker activity of T was investigated by determining T-bound ligand binding domain crystal structures of wild-type AR and a prostate cancer somatic...

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Share to Androgens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dihydrotestosterone

Share to Genitalia, Male

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Share to Receptors, Androgen

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Identifiers

PMID: 17591767
DOI: 10.1074/jbc.M703268200
PMCID: PMC4075031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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