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Article

A search for structurally similar cellular internal ribosome entry sites

25 Jun 2007

Abstract excerpt

Internal ribosome entry sites (IRES) allow ribosomes to be recruited to mRNA in a cap-independent manner. Some viruses that impair cap-dependent translation initiation utilize IRES to ensure that the viral RNA will efficiently compete for the translation machinery. IRES are also employed for the translation of a subset of cellular messages during conditions that inhibit cap-dependent translation initiation. IRES...

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PMID: 17591613
DOI: 10.1093/nar/gkm483

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